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Algenex’ core expertise is in the production of biotechnology products using Baculousvirus vectors

Baculovirus Expression Vector Systems (BEVS) are one of the most powerful, robust and versatile eukaryotic expression systems, significantly increasing the speed and versatility of expression of a wide variety of protein families allowing the acceleration of development times of protein-based pharmaceutical or diagnostic products.

CrisBio®

CrisBio® harnesses pupae from the Trichoplusia ni as living bioreactors to take recombinant protein production to the next level.

TopBac®

Pupae are "programmed" to produce recombinant proteins by inoculation with a virus containing Algenex' improved expression cassette TopBac®.

CrisBio® and Topbac® are propietary, patent protected technologies which can be applied in combination or on a stand-alone basis.

Improved baculousvirus vectors

Proprietary Baculousvirus expression cassette that allows significant yield increases, long-lasting expression and reduces protein proteolysis.

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Disruptive manufacturing process

Harnessing the power of insects to act as natural single-use bioreactors with chrysalises from the Trichoplusia ni Lepidopter as production tool.

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CrisBio®

Current production methods for recombinant proteins present a series of challenges in respect to development speed, scalability, technical complexity and cost.

CrisBio®, is an automated process that enables productivity of gram/litre levels with an extremely low investment and the upside of production flexibility and immediate scalability.

CrisBio® is a simple and robust process that has proven efficient in producing complex antigens.
CrisBio® uses pupae from the Trichoplusia ni, the natural host of the AcMNPV baculousvirus vector used in the commercial vaccine production.

CrisBio®
CrisBio®

> than 1mg of purified recombinant protein per insect in average

  • Simple manufacturing
  • Almost unlimited linear scalability
  • High versatility
  • High efficiency: Incorporates TopBac® as productivity booster
  • Significant savings in production costs

CrisBio® manufacturing process

Publications on CrisBio®

Sep 16

Rotavirus A-specific single-domain antibodies produced in ba...

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Sep 16

Development of a low-cost, insect larvae-derived recombinant...

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TopBac®

TopBac® is a proprietary patented expression cassette that comprises several genetic regulatory elements working in cascade. When incorporated into the genome of a baculovirus vector, TopBac® significantly improves the productivity and quality of recombinant proteins produced by host cells. TopBac® is fully compatible with the most common baculousvirus vector-based production technologies.

Publications on TopBac®

Sep 16

Improved Production Efficiency of Virus-Like Particles by th...

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Sep 16

Significant Productivity Improvement of the Baculovirus Expr...

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Sep 16

Download Top-Bac® flyer

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